• 靶点：
• FOXP3

• 简介：
• >>Th17 cell differentiation;>>Inflammatory bowel disease

• 基因名称：
• FOXP3

• 蛋白名称：
• Forkhead box protein P3

• Human Gene Id：
• 50943

• Human Swiss Prot No：
• Q9BZS1

• Mouse Gene Id：
• 20371

• Mouse Swiss Prot No：
• Q99JB6

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the C-terminal region of human FOXP3. AA range:381-430

• 特异性：
• FOXP3 Polyclonal Antibody detects endogenous levels of FOXP3 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FOXP3;IPEX;JM2;Forkhead box protein P3;Scurfin

• 实测条带：
• 47kD

• 背景：
• The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.,function:Probable transcription factor. Plays a critical role in the control of immune response.,online information:FOXP3 entry,online information:FOXP3 mutation db,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain.,

• 细胞定位：
• Nucleus . Cytoplasm . Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity). .

Immunophenotypes Based on the Tumor Immune Microenvironment Allow for Unsupervised Penile Cancer Patient Stratification. Cancers 2020 Jul 04 IHC Human 1:100 FFPE tumor tissue
货号：YT5446

Differential Effects of Breed and Nursing on Early-Life Colonic Microbiota and Immune Status as Revealed in a Cross-Fostering Piglet Model. APPLIED AND ENVIRONMENTAL MICROBIOLOGY Appl Environ Microb. 2019 May;: WB Pig 1:100 colonic tissue
货号：YT5446

Deletion of the C6orf120 gene with unknown function ameliorates autoimmune hepatitis induced by concanavalin A. CELLULAR IMMUNOLOGY Cell Immunol. 2018 Sep;331:9 IHC Rat 1:100 liver
货号：YT5446

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