• 靶点：
• Actin-α cardiac muscle

• 简介：
• >>Cardiac muscle contraction;>>Adrenergic signaling in cardiomyocytes;>>Hypertrophic cardiomyopathy;>>Dilated cardiomyopathy

• 基因名称：
• ACTC1

• 蛋白名称：
• Actin alpha cardiac muscle 1

• Human Gene Id：
• 70

• Human Swiss Prot No：
• P68032

• Mouse Gene Id：
• 11464

• Mouse Swiss Prot No：
• P68033

• Rat Gene Id：
• 29275

• Rat Swiss Prot No：
• P68035

• 免疫原：
• Synthesized peptide derived from Actin-α cardiac muscle . at AA range: 1-80

• 特异性：
• Actin-α cardiac muscle Polyclonal Antibody detects endogenous levels of Actin-α cardiac muscle protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ACTC1;ACTC;Actin, alpha cardiac muscle 1;Alpha-cardiac actin

• 实测条带：
• 42kD

• 背景：
• Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in ACTC1 are the cause of cardiomyopathy dilated type 1R (CMD1R) [MIM:102540]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,disease:Defects in ACTC1 are the cause of cardiomyopathy familial hypertrophic type 11 (CMH11) [MIM:612098]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,function:Actins are highly conserv

• 细胞定位：
• Cytoplasm, cytoskeleton.

• 组织表达：
• Muscle,Tongue,

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