• 靶点：
• WWOX

• 基因名称：
• WWOX

• 蛋白名称：
• WW domain-containing oxidoreductase

• Human Gene Id：
• 51741

• Human Swiss Prot No：
• Q9NZC7

• Mouse Gene Id：
• 80707

• Mouse Swiss Prot No：
• Q91WL8

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human WWOX. AA range:1-50

• 特异性：
• WWOX Polyclonal Antibody detects endogenous levels of WWOX protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• WWOX;FOR;WOX1;WW domain-containing oxidoreductase;Fragile site FRA16D oxidoreductase

• 实测条带：
• 47kD

• 背景：
• WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.

• 功能：
• skeletal system development, ossification, osteoblast differentiation, induction of apoptosis, steroid metabolic process, negative regulation of signal transduction, negative regulation of cell communication, regulation of cell death,positive regulation of cell death, induction of programmed cell death, regulation of Wnt receptor signaling pathway,negative regulation of Wnt receptor signaling pathway, regulation of apoptosis, positive regulation of apoptosis,regulation of programmed cell death, positive regulation of programmed cell death, skeletal system morphogenesis,oxidation reduction, bone development,

• 细胞定位：
• Cytoplasm . Nucleus . Mitochondrion . Golgi apparatus . Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus. .

• 组织表达：
• Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.

EBV-LMP1 regulating AKT/mTOR signaling pathway and WWOX in nasopharyngeal carcinoma. International Journal of Clinical and Experimental Pathology Int J Clin Exp Patho. 2017; 10(8): 8619–8625 WB Human CNE1-LMP1 cell,CNE1
货号：YT4909

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