Vav3 Polyclonal Antibody

    • 货号:YT4865
    • 应用:WB,ELISA
    • 种属:Human,Mouse
      • 基因名称:
      • VAV3
      • 蛋白名称:
      • Guanine nucleotide exchange factor VAV3
      • Human Swiss Prot No:
      • Q9UKW4
      • Mouse Swiss Prot No:
      • Q9R0C8
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from human VAV3. AA range:139-188
      • 特异性:
      • Vav3 Polyclonal Antibody detects endogenous levels of Vav3 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit
      • 稀释:
      • Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -20°C/1 year
      • 其他名称:
      • VAV3; Guanine nucleotide exchange factor VAV3; VAV-3
      • 分子量:
      • 97776
      • 实测条带:
      • 98
      • 背景:
      • vav guanine nucleotide exchange factor 3(VAV3) Homo sapiens This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
      • 功能:
      • function:Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with the PH domain of APS.,
      • 细胞定位:
      • intracellular,cytosol,plasma membrane,extracellular exosome,
      • 组织表达:
      • Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.
      • 产品图片
      • Western Blot analysis of 293T-UV cells using Vav3 Polyclonal Antibody diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Western blot analysis of the lysates from HepG2 cells using VAV3 antibody.