VAMP-4 Polyclonal Antibody

    • 货号:YT4851
    • 应用:IF;ELISA
    • 种属:Human;Mouse
      • 靶点:
      • VAMP4
      • 简介:
      • >>SNARE interactions in vesicular transport
      • 基因名称:
      • VAMP4
      • 蛋白名称:
      • Vesicle-associated membrane protein 4
      • Human Gene Id:
      • 8674
      • Human Swiss Prot No:
      • O75379
      • Mouse Swiss Prot No:
      • O70480
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from human VAMP4. AA range:1-50
      • 特异性:
      • VAMP-4 Polyclonal Antibody detects endogenous levels of VAMP-4 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • VAMP4;Vesicle-associated membrane protein 4;VAMP-4
      • 分子量:
      • 16kD
      • 背景:
      • Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008],
      • 功能:
      • function:Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subcellular location:Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.,subunit:Identified in a complex containing STX6, STX13, VAMP4 and VTI1A.,
      • 细胞定位:
      • Golgi apparatus, trans-Golgi network membrane ; Single-pass type IV membrane protein . Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.
      • 组织表达:
      • B-cell,Bone marrow,Epithelium,Liver,Urinary bladder,
      • 产品图片
      • Immunofluorescence analysis of A549 cells, using VAMP4 Antibody. The picture on the right is blocked with the synthesized peptide.