Protocadherin-11 Polyclonal Antibody

    • 货号:YT3863
    • 应用:IHC;IF;ELISA
    • 种属:Human;Rat;Mouse;
      • 靶点:
      • Protocadherin-11
      • 基因名称:
      • PCDH11X/PCDH11Y
      • 蛋白名称:
      • Protocadherin-11 X/Y-linked
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from human PCDH-X/Y. AA range:531-580
      • 特异性:
      • Protocadherin-11 Polyclonal Antibody detects endogenous levels of Protocadherin-11 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • PCDH11Y;PCDH11;PCDH22;PCDHY;Protocadherin-11 Y-linked;Protocadherin-11;Protocadherin on the Y chromosome;PCDH-Y;Protocadherin prostate cancer;Protocadherin-PC;Protocadherin-22;PCDH11X;KIAA1326;PCDH11;PCDHX;Protocadherin-11 X-
      • 分子量:
      • 147kD
      • 背景:
      • This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],
      • 功能:
      • alternative products:Additional isoforms seem to exist,disease:A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.,function:Potential calcium-dependent cell-adhesion protein.,similarity:Contains 7 cadherin domains.,subunit:Interacts with CTNNB1.,tissue specificity:Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.,
      • 细胞定位:
      • Cell membrane ; Single-pass type I membrane protein .
      • 组织表达:
      • Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.
      • 产品图片
      • Immunofluorescence analysis of HepG2 cells, using PCDH-X/Y Antibody. The picture on the right is blocked with the synthesized peptide.
      • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PCDH-X/Y Antibody. The picture on the right is blocked with the synthesized peptide.