• 靶点：
• KV3.1

• 基因名称：
• KCNC1

• 蛋白名称：
• Potassium voltage-gated channel subfamily C member 1

• Human Gene Id：
• 3746

• Human Swiss Prot No：
• P48547

• Mouse Gene Id：
• 16502

• Mouse Swiss Prot No：
• P15388

• Rat Gene Id：
• 25327

• Rat Swiss Prot No：
• P25122

• 免疫原：
• Synthesized peptide derived from KV3.1 . at AA range: 190-270

• 特异性：
• KV3.1 Polyclonal Antibody detects endogenous levels of KV3.1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• KCNC1;Potassium voltage-gated channel subfamily C member 1;NGK2;Voltage-gated potassium channel subunit Kv3.1;Voltage-gated potassium channel subunit Kv4

• 实测条带：
• 60kD

• 背景：
• This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014],

• 功能：
• domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,similarity:Belongs to the potassium channel family. C (Shaw) subfamily.,subunit:Heteromultimer with KCNG3, KCNG4 and KCNV2.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones. .

• 组织表达：
• PCR rescued clones,

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