• 靶点：
• ARX

• 基因名称：
• ARX

• 蛋白名称：
• Homeobox protein ARX

• Human Gene Id：
• 170302

• Human Swiss Prot No：
• Q96QS3

• Mouse Gene Id：
• 11878

• Mouse Swiss Prot No：
• O35085

• Rat Gene Id：
• 317268

• Rat Swiss Prot No：
• A6YP92

• 免疫原：
• Synthesized peptide derived from ARX . at AA range: 250-330

• 特异性：
• ARX Polyclonal Antibody detects endogenous levels of ARX protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ARX;Homeobox protein ARX;Aristaless-related homeobox

• 实测条带：
• 55kD

• 背景：
• This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is thought to be involved in CNS development. Expansion of a polyalanine tract and other mutations in this gene cause X-linked mental retardation and epilepsy. [provided by RefSeq, Jul 2016],

• 功能：
• disease:Defects in ARX are a cause of Partington syndrome (PRTS) [MIM:309510]; also known as X-linked syndromic mental retardation 1 (MRXS1). PRTS is characterized by mental retardation, episodic dystonic hand movements, and dysarthria.,disease:Defects in ARX are the cause of agenesis of corpus callosum with abnormal genitalia (ACC with abnormal genitalia) [MIM:300004]. ACC with abnormal genitalia consists of a brain and genital malformations syndrome.,disease:Defects in ARX are the cause of epileptic encephalopathy early infantile type 1 (EIEE1) [MIM:308350]; also known as myoclonic epilepsy X-linked with intellectual disability and spasticity, X-linked West syndrome or X-linked infantile spasm syndrome (ISSX). EIEE1 is a severe form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterize

• 细胞定位：
• Nucleus .

• 组织表达：
• Expressed predominantly in fetal and adult brain and skeletal muscle. Expression is specific to the telencephalon and ventral thalamus. There is an absence of expression in the cerebellum throughout development and also in adult.

Mof regulates glucose level via altering different α-cell subset mass and intra-islet glucagon-like peptide-1, glucagon secretion. METABOLISM-CLINICAL AND EXPERIMENTAL Metabolism. 2020 Aug;109:154290 WB Mouse 1:500 α-TC1-6
货号：YT0346

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