AF-4 Polyclonal Antibody

    • 货号:YT0140
    • 应用:IHC;IF;WB;ELISA
    • 种属:Human;Mouse
      • 靶点:
      • AF-4
      • 简介:
      • >>Transcriptional misregulation in cancer
      • 基因名称:
      • AFF1
      • 蛋白名称:
      • AF4/FMR2 family member 1
      • Human Gene Id:
      • 4299
      • Human Swiss Prot No:
      • P51825
      • Mouse Swiss Prot No:
      • O88573
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from human AF4. AA range:1-50
      • 特异性:
      • AF-4 Polyclonal Antibody detects endogenous levels of AF-4 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • AFF1;AF4;FEL;MLLT2;PBM1;AF4/FMR2 family member 1;ALL1-fused gene from chromosome 4 protein;Protein AF-4;Protein FEL;Proto-oncogene AF4
      • 实测条带:
      • 130kD
      • 背景:
      • This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in mu
      • 功能:
      • disease:A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein.,similarity:Belongs to the AF4 family.,
      • 细胞定位:
      • Nucleus .
      • 组织表达:
      • Epithelium,PCR rescued clones,Placenta,
      • 产品图片
      • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using AF4 Antibody. The picture on the right is blocked with the synthesized peptide.