ABCB7 Polyclonal Antibody

    • 货号:YT0046
    • 应用:WB;IHC;IF;ELISA
    • 种属:Human;Rat;Mouse;
      • 靶点:
      • ABCB7
      • 简介:
      • >>ABC transporters
      • 基因名称:
      • ABCB7
      • 蛋白名称:
      • ATP-binding cassette sub-family B member 7 mitochondrial
      • Human Gene Id:
      • 22
      • Human Swiss Prot No:
      • O75027
      • Mouse Swiss Prot No:
      • Q61102
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from human ABCB7. AA range:691-740
      • 特异性:
      • ABCB7 Polyclonal Antibody detects endogenous levels of ABCB7 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • ABCB7;ABC7;ATP-binding cassette sub-family B member 7; mitochondrial;ATP-binding cassette transporter 7;ABC transporter 7 protein
      • 实测条带:
      • Human:83kD,Mouse/Rat 100kD
      • 背景:
      • The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms hav
      • 功能:
      • disease:Defects in ABCB7 are the cause of X-linked sideroblastic anemia with ataxia (ASAT) [MIM:301310]. ASAT is a recessive disorder characterized by an infantile to early childhood onset of nonprogressive cerebellar ataxia and mild anemia with hypochromia and microcytosis.,function:Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.,similarity:Belongs to the ABC transporter family. Heavy Metal importer (TC 3.A.1.210) subfamily.,similarity:Contains 1 ABC transmembrane type-1 domain.,similarity:Contains 1 ABC transporter domain.,subunit:Homodimer or heterodimer .,
      • 细胞定位:
      • Mitochondrion inner membrane ; Multi-pass membrane protein .
      • 组织表达:
      • Human esophagus tumor,Muscle,Placenta,Umbilical cord blood,
      • 产品图片
      • Western Blot analysis of various cells using ABCB7 Polyclonal Antibody diluted at 1:1000
      • Western Blot analysis of various cells using antibody diluted at 1:1000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Immunohistochemistry analysis of paraffin-embedded human thymus gland, using ABCB7 Antibody. The picture on the right is blocked with the synthesized peptide.
      • Western blot analysis of the lysates from HUVECcells using ABCB7 antibody.