• 靶点：
• PDGFR-β

• 简介：
• >>EGFR tyrosine kinase inhibitor resistance;>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>Phospholipase D signaling pathway;>>PI3K-Akt signaling pathway;>>Focal adhesion;>>Gap junction;>>JAK-STAT signaling pathway;>>Regulation of actin cytoskeleton;>>Human papillomavirus infection;>>Pathways in cancer;>>MicroRNAs in cancer;>>Glioma;>>Prostate cancer;>>Melanoma;>>Central carbon metabolism in cancer;>>Choline metabolism in cancer

• 基因名称：
• PDGFRB PDGFR PDGFR1

• 蛋白名称：
• Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-

• Human Gene Id：
• 5159

• Human Swiss Prot No：
• P09619

• Mouse Gene Id：
• 18596

• Mouse Swiss Prot No：
• P05622

• Rat Gene Id：
• 24629

• Rat Swiss Prot No：
• Q05030

• 免疫原：
• Synthesized peptide derived from human PDGFRb (Phospho Tyr579+Tyr581)

• 特异性：
• This antibody detects endogenous levels of PDGFRb (Phospho Tyr579+Tyr581) Rabbit pAb at Human, Mouse,Rat

• 组成：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• 来源：
• Rabbit,polyclonal

• 稀释：
• WB 1:500-2000 IHC 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PDGFRB;PDGFR;PDGFR1;Platelet-derived growth factor receptor beta;PDGF-R-beta;PDGFR-beta;Beta platelet-derived growth factor receptor;Beta-type platelet-derived growth factor receptor;CD140 antigen-like family member B;Platelet-deri

• 实测条带：
• 135-180kD

• 背景：
• platelet derived growth factor receptor beta(PDGFRB) Homo sapiens This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving PDGFRB is a cause in many instances of chronic myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t(5;12) with ETV6 on chromosome 12 creating an PDGFRB-ETV6 fusion protein.,disease:A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with EVT6/TEL. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).,disease:A chromosomal aberration involving PDGFRB may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with TRIP11. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.,disease:A chromosomal aberration involving PDGFRB may be a cause

• 细胞定位：
• Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.

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