BTK (Phospho Ser179) Rabbit pAb

    • 货号:YP1838
    • 应用:IHC;WB
    • 种属:Human;Mouse
      • 靶点:
      • Btk
      • 简介:
      • >>NF-kappa B signaling pathway;>>Osteoclast differentiation;>>Platelet activation;>>B cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>Epstein-Barr virus infection;>>Primary immunodeficiency
      • 基因名称:
      • BTK AGMX1 ATK BPK
      • 蛋白名称:
      • Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
      • 序列:
      • Q06187
      • Human Gene Id:
      • 695
      • Human Swiss Prot No:
      • Q06187
      • Mouse Swiss Prot No:
      • P35991
      • 免疫原:
      • Synthesized peptide derived from human BTK (Phospho Ser179)
      • 特异性:
      • This antibody detects endogenous levels of BTK (Phospho Ser179) Rabbit pAb at Human, Mouse
      • 组成:
      • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
      • 来源:
      • Rabbit,polyclonal
      • 稀释:
      • WB 1:500-2000 IHC 1:50-200
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
      • 实测条带:
      • 80kD
      • 背景:
      • Bruton tyrosine kinase(BTK) Homo sapiens The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013],
      • 功能:
      • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,cofactor:Binds 1 zinc ion per subunit.,disease:Defects in BTK are the cause of X-linked agammaglobulinemia (XLA) [MIM:300755]; also called X-linked agammaglobulinemia type 1 (AGMX1) or immunodeficiency type 1 (IMD1). XLA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of all classes and leads to recurrent bacterial infections like otitis, conjunctivitis, dermatitis, sinusitis in the first few years of life, or even some patients present overwhelming sepsis or meningitis, resulting in death in a few hours. Treatment in most cases is by infusion of intravenous immunoglobulin.,
      • 细胞定位:
      • Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1.
      • 组织表达:
      • Predominantly expressed in B-lymphocytes.
      • 产品图片
      • Western Blot analysis of mouse heart ,using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000