EPH B1/3/4 (Phospho Tyr778/792/774) rabbit pAb

  • 货号:YP1726
  • 应用:WB
  • 种属:Human;Mouse;Rat
    • 靶点:
    • EPHB1/3/4
    • 简介:
    • >>Axon guidance
    • 基因名称:
    • EPHB1 ELK EPHT2 HEK6 NET
    • 蛋白名称:
    • EPH B1/3/4 (Phospho-Tyr778/792/774)
    • Human Gene Id:
    • 2047
    • Human Swiss Prot No:
    • P54762
    • Mouse Swiss Prot No:
    • Q8CBF3
    • 免疫原:
    • Synthesized peptide derived from human EPH B1/3/4 (Phospho-Tyr778/792/774)
    • 特异性:
    • This antibody detects endogenous levels of EPH B1/3/4 (Phospho-Tyr778/792/774) at Human, Mouse,Rat
    • 组成:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源:
    • Polyclonal, Rabbit,IgG
    • 稀释:
    • WB 1:500-2000
    • 纯化工艺:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • 浓度:
    • 1 mg/ml
    • 储存:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称:
    • Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
    • 分子量:
    • 108kD
    • 背景:
    • Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008],
    • 功能:
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-B family. Binds to ephrin-B1, -B2 and -B3. May be involved in cell-cell interactions in the nervous system.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:The ligand-activated form interacts with GRB2, GRB10 and NCK through their respective SH2 domains. The GRB10 SH2 domain binds EPHB1 through Tyr-928, while GRB2 binds residues within the catalytic domain. Interacts with EPHB6. The NCK SH2 domain binds EPHB1 through Tyr-594. Interacts with PRKCABP.,tissue specificity:Preferentially expressed in brain.,
    • 细胞定位:
    • Cell membrane ; Single-pass type I membrane protein . Early endosome membrane . Cell projection, dendrite .
    • 组织表达:
    • Preferentially expressed in brain.