ZAK (Phospho-Ser165) rabbit pAb

  • 货号:YP1725
  • 应用:WB
  • 种属:Human, Mouse,Rat
    • 基因名称:
    • MLTK ZAK HCCS4
    • 蛋白名称:
    • ZAK (Phospho-Ser165)
    • Human Swiss Prot No:
    • Q9NYL2
    • Mouse Swiss Prot No:
    • Q9ESL4
    • Rat Gene Id:
    • 0
    • Rat Swiss Prot No:
    • 0
    • 免疫原:
    • Synthesized peptide derived from human ZAK (Phospho-Ser165)
    • 特异性:
    • This antibody detects endogenous levels of ZAK (Phospho-Ser165) at Human, Mouse,Rat
    • 组成:
    • Liquid in PBS containing 50% glycerol, and 0.152% sodium azide.
    • 来源:
    • Rabbit,polyclonal
    • 稀释:
    • WB 1:500-2000
    • 纯化工艺:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • 浓度:
    • 1 mg/ml
    • 储存:
    • -20°C/1 year
    • 其他名称:
    • Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
    • 分子量:
    • 88000
    • 背景:
    • sterile alpha motif and leucine zipper containing kinase AZK(ZAK) Homo sapiens This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
    • 功能:
    • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation by PKN1 and autophosphorylation on Thr-161 and Ser-165.,function:Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,subcellular location:Tr
    • 细胞定位:
    • Cytoplasm . Nucleus . Translocates to the nucleus upon ultraviolet B irradiation. .
    • 组织表达:
    • Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.