EPHA3 (Phospho Tyr602) rabbit pAb

  • 货号:YP1608
  • 应用:WB;ELISA
  • 种属:Human;Mouse;Rat
    • 靶点:
    • EPHA3
    • 简介:
    • >>Axon guidance
    • 基因名称:
    • EPHA3 ETK ETK1 HEK TYRO4
    • 蛋白名称:
    • EPHA3 (Phospho Tyr602)
    • Human Gene Id:
    • 2042
    • Human Swiss Prot No:
    • P29320
    • Mouse Swiss Prot No:
    • P29319
    • 免疫原:
    • Synthesized peptide derived from human EPHA3 (Phospho Tyr602)
    • 特异性:
    • This antibody detects endogenous levels of Human,Mouse,Rat EPHA3 (Phospho Tyr602)
    • 组成:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源:
    • Polyclonal, Rabbit,IgG
    • 稀释:
    • WB 1:1000-2000 ELISA 1:5000-20000
    • 纯化工艺:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • 浓度:
    • 1 mg/ml
    • 储存:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称:
    • Ephrin type-A receptor 3 (EC 2.7.10.1;EPH-like kinase 4;EK4;hEK4;HEK;Human embryo kinase;Tyrosine-protein kinase TYRO4;Tyrosine-protein kinase receptor ETK1;Eph-like tyrosine kinase 1)
    • 实测条带:
    • 130kD
    • 背景:
    • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],
    • 功能:
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Widely expressed. Highest level in placenta.,
    • 细胞定位:
    • [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
    • 组织表达:
    • Widely expressed. Highest level in placenta.