SSH3 (Phospho Ser37) rabbit pAb
- 货号：YP1511
- 应用：WB
- 种属：Human;Rat;Mouse;
- 简介：
- >>Axon guidance;>>Regulation of actin cytoskeleton
- 免疫原：
- Synthesized phosho peptide around human SSH3 (Ser37)
- 特异性：
- This antibody detects endogenous levels of Human SSH3 (phospho-Ser37)
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 纯化工艺：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L)
- 背景：
- The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008],
- 功能：
- catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.,miscellaneous:Tyrosine phosphatase activity has not been demonstrated for this protein to date.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Does not bind to, or colocalize with, filamentous actin.,
- 细胞定位：
- Cytoplasm, cytoskeleton . Nucleus .
- 组织表达：
- Cerebellum,Epithelium,Ovarian carcinoma,Uterus,
