Numb (Phospho Ser276) rabbit pAb

  • 货号:YP1424
  • 应用:WB
  • 种属:Human;Rat;Mouse;
    • 靶点:
    • Numb
    • 简介:
    • >>Notch signaling pathway
    • 基因名称:
    • NUMB
    • 蛋白名称:
    • Numb (Ser276)
    • Human Gene Id:
    • 8650
    • Human Swiss Prot No:
    • P49757
    • Mouse Swiss Prot No:
    • Q9QZS3
    • 免疫原:
    • Synthesized phosho peptide around human Numb (Ser276)
    • 特异性:
    • This antibody detects endogenous levels of Human Numb (phospho-Ser276)
    • 组成:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源:
    • Polyclonal, Rabbit,IgG
    • 稀释:
    • WB 1:1000-2000
    • 纯化工艺:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • 浓度:
    • 1 mg/ml
    • 储存:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称:
    • Protein numb homolog (h-Numb) (Protein S171)
    • 实测条带:
    • 70kD
    • 背景:
    • The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
    • 功能:
    • function:Implicated in the control of cell fate decisions during development.,PTM:Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,sequence caution:Intron retention.,similarity:Contains 1 PID domain.,subunit:Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.,
    • 细胞定位:
    • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. .
    • 组织表达:
    • B cells,Blood,Brain,Cervix carcinoma,Epithelium,Fetal brain,HeLa cells,Live