NF-κB2 p100 (phospho-Ser866/870) rabbit pAb

  • 货号:YP1419
  • 应用:WB
  • 种属:Human,Mouse
    • 基因名称:
    • NFKB2 LYT10
    • 蛋白名称:
    • NF-κB2 p100 (Ser866/870)
    • Human Gene Id:
    • 4791
    • Human Swiss Prot No:
    • Q00653
    • Mouse Swiss Prot No:
    • Q9WTK5
    • 免疫原:
    • Synthesized phosho peptide around human NF-κB2 p100 (Ser866 and 870)
    • 特异性:
    • This antibody detects endogenous levels of Human Mouse NF-κB2 p100 (phospho-Ser866 or 870)
    • 组成:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源:
    • Rabbit
    • 稀释:
    • WB 1:1000-2000
    • 纯化工艺:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • 浓度:
    • 1 mg/ml
    • 储存:
    • -20°C/1 year
    • 其他名称:
    • Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
    • 实测条带:
    • 100
    • 背景:
    • nuclear factor kappa B subunit 2(NFKB2) Homo sapiens This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
    • 功能:
    • disease:A chromosomal aberration involving NFKB2 is found in a case of B-cell non Hodgkin lymphoma (B-NHL). Translocation t(10;14)(q24;q32) with IGHA1. The resulting oncogene is also called Lyt-10C alpha variant.,disease:A chromosomal aberration involving NFKB2 is found in a cutaneous T-cell leukemia (C-TCL) cell line. This rearrangement produces the p80HT gene which encodes for a truncated 80 kDa protein (p80HT).,disease:In B-cell leukemia (B-CLL) cell line, LB40 and EB308, can be found after heterogeneous chromosomal aberrations, such as internal deletions.,domain:The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52 homodimers, and/or transcription activation.,domain:The glycine-rich region (GRR) appears to be a critical element in the generation of p52.,function:NF-kappa-B is a pleiotropic transcription factor which is present in almost a
    • 细胞定位:
    • nucleus,nucleoplasm,cytoplasm,cytosol,Bcl3/NF-kappaB2 complex,
    • 组织表达:
    • Leukemia,Lymph,Thymus,