MYH9 Polyclonal Antibody

  • 货号：YN2974
  • 应用：WB;ELISA
  • 种属：Human;Mouse;Rat
    • 靶点：
    • MYH9
    • 简介：
    • >>Vascular smooth muscle contraction;>>Tight junction;>>Regulation of actin cytoskeleton;>>Pathogenic Escherichia coli infection
    • 基因名称：
    • MYH9
    • 蛋白名称：
    • Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a)
    • Human Gene Id：
    • 4627
    • Human Swiss Prot No：
    • P35579
    • Mouse Swiss Prot No：
    • Q8VDD5
    • 免疫原：
    • Synthesized peptide derived from part region of human protein
    • 特异性：
    • MYH9 Polyclonal Antibody detects endogenous levels of protein.
    • 组成：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • WB 1:500-2000 ELISA 1:5000-20000
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 实测条带：
    • 215kD
    • 背景：
    • This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011],
    • 功能：
    • disease:Defects in MYH9 are the cause of Alport syndrome with macrothrombocytopenia (APSM) [MIM:153650]. APSM is an autosomal dominant disorder characterized by the association of ocular lesions, sensorineural hearing loss and nephritis (Alport syndrome) with platelet defects.,disease:Defects in MYH9 are the cause of Epstein syndrome (EPS) [MIM:153650]. EPS is an autosomal dominant disorder characterized by the association of macrothrombocytopathy, sensorineural hearing loss and nephritis.,disease:Defects in MYH9 are the cause of Fechtner syndrome (FTNS) [MIM:153640]. FTNS is an autosomal dominant macrothrombocytopenia characterized by thrombocytopenia, giant platelets and leukocyte inclusions that are small and poorly organized. Additionally, FTNS is distinguished by Alport-like clinical features of sensorineural deafness, cataracts and nephritis.,disease:Defects in MYH9 are the cause o
    • 细胞定位：
    • Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Cytoplasmic vesicle, secretory vesicle, Cortical granule . Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610). .
    • 组织表达：
    • In the kidney, expressed in the glomeruli. Also expressed in leukocytes.

    相关报价

    • 货号：
    • YN2974
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • 960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-04-20
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