• 靶点：
• N-Cadherin

• 简介：
• >>Cell adhesion molecules;>>Arrhythmogenic right ventricular cardiomyopathy

• 基因名称：
• CDH2 CDHN NCAD

• 蛋白名称：
• Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)

• Human Gene Id：
• 1000

• Human Swiss Prot No：
• P19022

• 免疫原：
• Synthesized peptide derived from human N-Cadherin AA range: 200-400

• 特异性：
• This antibody detects endogenous levels of human N-Cadherin. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Mouse, Monoclonal/IgG2b, Kappa

• 稀释：
• IHC 1:200-400,WB 1:500-2000, ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 100kD

• 背景：
• This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015],

• 功能：
• function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism.,similarity:Contains 5 cadherin domains.,subunit:Interacts with CDCP1.,

• 细胞定位：
• Cell membrane ; Single-pass type I membrane protein . Cell membrane, sarcolemma . Cell junction . Cell surface . Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes. .

• 组织表达：
• Brain,Epithelium,Liver,

TP53I11 suppresses epithelial-mesenchymal transition and metastasis of breast cancer cells. BMB Reports Bmb Rep. 2019 Jun; 52(6): 379–384 WB Human MDA-MB-231 cell
货号：YM6590

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