p57kip2 (ABT-P57) mouse mAb
- 货号:YM6205
- 应用:WB;IHC;ELISA
- 种属:Human;
- 蛋白名称:
- Beckwith Wiedemann syndrome;BWCR;BWS;CDKI;CDKN 1C;CDKN1C;CDN1C_HUMAN;Cyclin dependent kinase inhibitor 1C;Cyclin dependent kinase inhibitor p57;Cyclin-dependent kinase inhibitor 1C;Cyclin-dependent ki
- 免疫原:
- Synthesized peptide derived from human p57kip2 AA range: 200-316
- 特异性:
- This antibody detects endogenous levels of p57kip2 protein
- 组成:
- PBS, pH7.4, 50% glycerol, 0.05% Proclin 300
- 来源:
- Mouse, Monoclonal/IgG2a, Kappa
- 稀释:
- IHC 1:200-400, WB 1:500-2000, ELISA 1:5000-20000
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- Beckwith Wiedemann syndrome;BWCR;BWS;CDKI;CDKN 1C;CDKN1C;CDN1C_HUMAN;Cyclin dependent kinase inhibitor 1C;Cyclin dependent kinase inhibitor p57;Cyclin-dependent kinase inhibitor 1C;Cyclin-dependent kinase inhibitor p57;KIP 2;KIP2;p57;p57 Kip 2;p57KIP2;WBS
- 背景:
- This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],
- 功能:
- disease:Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.,disease:Defects in CDKN1C are involved in tumor formation.,function:Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels ar
- Whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-p57kip2 (ABT-P57)antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody.
Lane 1: Jurkat
Predicted band size: 57kDa
Observed band size: 57kDa
- Human Kidney tissue was stained with Anti-p57kip2 (ABT-P57) Antibody
- Human placenta tissue was stained with Anti-p57kip2 (ABT-P57) Antibody