c-MYC (PTR2340) Mouse mAb
- 货号:YM4677
- 应用:WB;ELISA
- 种属:Human (predicted: Mouse; Rat)
- 简介:
- >>MAPK signaling pathway;>>ErbB signaling pathway;>>Cell cycle;>>PI3K-Akt signaling pathway;>>Cellular senescence;>>Wnt signaling pathway;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Signaling pathways regulating pluripotency of stem cells;>>JAK-STAT signaling pathway;>>Thyroid hormone signaling pathway;>>Salmonella infection;>>Hepatitis C;>>Hepatitis B;>>Human cytomegalovirus infection;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Proteoglycans in cancer;>>MicroRNAs in cancer;>>Chemical carcinogenesis - receptor activation;>>Colorectal cancer;>>Endometrial cancer;>>Thyroid cancer;>>Bladder cancer;>>Chronic myeloid leukemia;>>Acute myeloid leukemia;>>Small cell lung cancer;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer;>>Central carbon metabolism in cancer
- 蛋白名称:
- Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
- 免疫原:
- Synthesized peptide derived from human c-MYC AA range: 340-438
- 特异性:
- This antibody detects endogenous levels of c-MYC at Human, Mouse,Rat
- 组成:
- PBS, pH7.4, 50% glycerol, 0.03%Proclin 300
- 来源:
- Mouse, monoclonal IgG2b,Kappa
- 稀释:
- WB 1:500-2000 ELISA 1:5000-20000
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
- 背景:
- v-myc avian myelocytomatosis viral oncogene homolog(MYC) Homo sapiens The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008],
- 功能:
- disease:A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.,disease:Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.,function:Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.,online information:Myc entry,PTM:Phosphorylated by PRKDC.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B.,
- 细胞定位:
- Nucleus, nucleoplasm . Nucleus, nucleolus .
- Human prostate tissue was stained with Anti-c-MYC (PTR2340) Antibody
- Human skin tissue was stained with Anti-c-MYC (PTR2340) Antibody
- Human tonsil tissue was stained with Anti-c-MYC (PTR2340) Antibody
- Whole cell lysates of MDCK were separated by 12% SDS-PAGE, and the membrane was blotted with anti-C-Myc(PTR2340) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody.
Lane 1: MDCK
Predicted band size: 49kDa
Observed band size: 57kDa
- Whole cell lysates of NIH-3T3 were separated by 12% SDS-PAGE, and the membrane was blotted with anti-C-Myc(PTR2340) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody.
Lane 1: NIH-3T3
Predicted band size: 49kDa
Observed band size: 57kDa
- Whole cell lysates of A549 were separated by 12% SDS-PAGE, and the membrane was blotted with anti-C-Myc antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody.
Lane 1: A549
Predicted band size: 49kDa
Observed band size: 57kDa