• 靶点：
• Nrf2

• 简介：
• >>Protein processing in endoplasmic reticulum;>>Parkinson disease;>>Pathways in cancer;>>Chemical carcinogenesis - reactive oxygen species;>>Hepatocellular carcinoma;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis

• 基因名称：
• NFE2L2 NRF2

• 蛋白名称：
• Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)

• Human Gene Id：
• 4780

• Human Swiss Prot No：
• Q16236

• Mouse Gene Id：
• 18024

• Mouse Swiss Prot No：
• Q60795

• Rat Gene Id：
• 83619

• Rat Swiss Prot No：
• O54968

• 免疫原：
• Synthesized peptide derived from human Nrf2 AA range: 300-400

• 特异性：
• This antibody detects endogenous levels of Nrf2 at Human, Mouse,Rat

• 组成：
• PBS, pH7.4, 50% glycerol, 0.03%Proclin 300

• 来源：
• Monoclonal, Mouse IgG, Kappa

• 稀释：
• WB 1:500-2000,ELISA 1:5000-20000

• 纯化工艺：
• Protein G

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)

• 实测条带：
• 75-100kD

• 背景：
• nuclear factor, erythroid 2 like 2(NFE2L2) Homo sapiens This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015],

• 功能：
• domain:Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus.,function:Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.,PTM:Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. CNC subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electr

• 细胞定位：
• Cytoplasm, cytosol . Nucleus . Cytosolic under unstressed conditions: ubiquitinated and degraded by the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:15601839, PubMed:21196497). Translocates into the nucleus upon induction by electrophilic agents that inactivate the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:21196497). .

• 组织表达：
• Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

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