Syntenin-1 Monoclonal Antibody

    • 货号:YM1100
    • 应用:WB
    • 种属:Human;Rat;Dog;Pig
      • 靶点:
      • Syntenin-1
      • 基因名称:
      • SDCBP
      • 蛋白名称:
      • Syntenin-1
      • Human Gene Id:
      • 6386
      • Human Swiss Prot No:
      • O00560
      • Mouse Swiss Prot No:
      • O08992
      • 免疫原:
      • Purified recombinant human Syntenin-1 protein fragments expressed in E.coli.
      • 特异性:
      • Syntenin-1 Monoclonal Antibody detects endogenous levels of Syntenin-1 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Monoclonal, Mouse
      • 稀释:
      • WB 1:1000 - 1:2000. Not yet tested in other applications.
      • 纯化工艺:
      • Affinity purification
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • SDCBP;MDA9;SYCL;Syntenin-1;Melanoma differentiation-associated protein 9;MDA-9;Pro-TGF-alpha cytoplasmic domain-interacting protein 18;TACIP18;Scaffold protein Pbp1;Syndecan-binding protein 1
      • 分子量:
      • 32kD
      • 背景:
      • syndecan binding protein(SDCBP) Homo sapiens The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
      • 功能:
      • function:Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.,induction:By gamma interferon in melanoma cells.,PTM:Phosphorylated on tyrosine residues.,similarity:Contains 2 PDZ (DHR) domains.,subcellular location:Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Monomer and homodimer (By similarity). Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TG
      • 细胞定位:
      • Cell junction, focal adhesion . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus . Melanosome . Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Secreted, extracellular exosome . Membrane raft . Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966). .
      • 组织表达:
      • Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.
      • 产品图片
      • Western Blot analysis using Syntenin-1 Monoclonal Antibody against HeLa nuclear extract, HeLa cell lysate.