Integrin α6 Monoclonal Antibody

    • 货号:YM1055
    • 应用:WB;IF
    • 种属:Human;Mouse;Rat;Bovine;Dog;Pig
      • 靶点:
      • Integrin α6
      • 简介:
      • >>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Cell adhesion molecules;>>Hematopoietic cell lineage;>>Regulation of actin cytoskeleton;>>Toxoplasmosis;>>Human papillomavirus infection;>>Pathways in cancer;>>Small cell lung cancer;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy
      • 基因名称:
      • ITGA6
      • 蛋白名称:
      • Integrin alpha-6
      • Human Gene Id:
      • 3655
      • Human Swiss Prot No:
      • P23229
      • Mouse Swiss Prot No:
      • Q61739
      • 免疫原:
      • Purified recombinant human Integrin α6 (N-terminus) protein fragments expressed in E.coli.
      • 特异性:
      • Integrin α6 Monoclonal Antibody detects endogenous levels of Integrin α6 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Monoclonal, Mouse
      • 稀释:
      • WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
      • 纯化工艺:
      • Affinity purification
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • ITGA6;Integrin alpha-6;CD49 antigen-like family member F;VLA-6;CD antigen CD49f
      • 分子量:
      • 127kD
      • 背景:
      • integrin subunit alpha 6(ITGA6) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
      • 功能:
      • alternative products:Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha-6X1A, isoform Alpha-6X1B and isoform Alpha-6X1X2A (minor). Experimental confirmation may be lacking for some isoforms,disease:Defects in ITGA6 are a cause of epidermolysis bullosa with pyloric atresia (EB-PA) [MIM:226730]; also known as aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive disease characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus.,function:Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.,PTM:Isoforms containing segme
      • 细胞定位:
      • Cell membrane ; Single-pass type I membrane protein . Cell membrane ; Lipid-anchor .
      • 组织表达:
      • Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Processed integrin alpha-6: Expressed at low levels in normal prostate tissue with elevated levels in prostate cancer tissue (at protein level) (PubMed:15023541).
      • 产品图片
      • Western Blot analysis using Integrin α6 Monoclonal Antibody against 293, HepG2 cell lysate.