HABP2 (50k heavy chain, Cleaved-Arg313) rabbit pAb

  • 货号：YC0167
  • 应用：WB;ELISA
  • 种属：Human;Mouse;Rat
    • 靶点：
    • HABP2
    • 基因名称：
    • HABP2 HGFAL PHBP
    • 蛋白名称：
    • HABP2 (50k heavy chain, Cleaved-Arg313)
    • Human Gene Id：
    • 3026
    • Human Swiss Prot No：
    • Q14520
    • Mouse Swiss Prot No：
    • Q8K0D2
    • 免疫原：
    • Synthesized peptide derived from human HABP2 (50k heavy chain, Cleaved-Arg313)
    • 特异性：
    • This antibody detects endogenous levels of Human,Mouse,Rat HABP2 (50k heavy chain, Cleaved-Arg313, protein was cleaved amino acid sequence between 313-314 )
    • 组成：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • WB 1:1000-2000 ELISA 1:5000-20000
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称：
    • Hyaluronan-binding protein 2 (EC 3.4.21.-;Factor VII-activating protease;Factor seven-activating protease;FSAP;Hepatocyte growth factor activator-like protein;Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain;Hyaluronan-binding protein 2 50 kDa heavy chain alternate form;Hyaluronan-binding protein 2 27 kDa light chain;Hyaluronan-binding protein 2 27 kDa light chain alternate form]
    • 实测条带：
    • 50 77kD
    • 背景：
    • This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016],
    • 功能：
    • function:Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.,PTM:Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments.,similarity:Belongs to the peptidase
    • 细胞定位：
    • Secreted . Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
    • 组织表达：
    • Ubiquitously expressed.

    相关报价

    • 货号：
    • YC0167
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • 960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-04-25
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