YM201636

    • 货号:MC0454
      • CasNo:
      • 371942-69-7
      • 分子式:
      • C25H21N7O3
      • 纯度:
      • >98%
      • 靶点:
      • PIKfyve
      • IC50:
      • IC50: 33 nM (PIKfyve)[1]
      • 体外研究:
      • Acute treatment of cells with YM-201636 shows that the PIKfyve pathway is involved in the sorting of endosomal transport, with inhibition leading to the accumulation of a late endosomal compartment and blockade of retroviral exit. The yeast orthologue of PIKfyve, Fab1, is found to be insensitive to YM-201636 (IC50>5 μM). YM-201636 does not inhibit a type IIγ PtdInsP kinase even at 10 μM and inhibits a mouse type Iα PtdInsP kinase with an IC50>2 μM[1]. YM-201636 almost completely inhibits basal and insulin-activated 2-deoxyglucose uptake at doses as low as 160 nM, with IC50=54 nM for the net insulin response. YM-201636 also completely inhibits insulin-dependent activation of class IA PI 3-kinase[2]. At low doses (10-25 nM), YM-201636 inhibits preferentially PtdIns5P rather than PtdIns(3,5)P2 production, whereas at higher doses, the two products are similarly inhibited. YM-201636 at 160 nM inhibits PtdIns5P synthesis twice more effectively compared with PtdIns(3,5)P2 synthesis[3]. MDCK c
      • 体内研究:
      • 简介:
      • YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α.
      • 特异性:
      • Target: PIKfyve. Fields: YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α.
      • 稀释:
      • IC50: 33 nM (PIKfyve)[1]
      • 浓度:
      • >98%
      • 储存:
      • 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
      • 其他名称:
      • YM 201636; YM-201636
      • 分子量:
      • 467.48
      • 产品图片