VX-11e(TCS ERK 11e)

    • 货号:MC0397
      • CasNo:
      • 896720-20-0
      • 分子式:
      • C24H20Cl2FN5O2
      • 纯度:
      • >98%
      • 靶点:
      • ERK
      • IC50:
      • No data
      • 体外研究:
      • VX-11e is active in the HT29 cell proliferation assay (IC50=48 nM)[1].
      • 体内研究:
      • VX-11e is orally bioavailable in both rat and mice[1]. VX-11e (50 mg/kg, p.o.) results in robust inhibition of pRSK, and inhibits tumor growth in NSG mice bearing human melanoma RPDX tumors. VX-11e with BKM120 significantly improves tumor growth inhibition[2].
      • 简介:
      • VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase); antitumor agent.
      • 特异性:
      • Target: ERK. Fields: VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase); antitumor agent.
      • 稀释:
      • 浓度:
      • >98%
      • 储存:
      • 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
      • 其他名称:
      • VX 11e,vx11 e, tcs erk 11e
      • 分子量:
      • 500.35
      • 产品图片