AdipoRon

    • 货号:MC0297
      • CasNo:
      • 924416-43-3
      • 分子式:
      • C27H28N2O3
      • 纯度:
      • >98%
      • 靶点:
      • Adiponectin Receptor
      • IC50:
      • Kd: 1.8 μM (AdipoR1), 3.1 μM (AdipoR2)
      • 体外研究:
      • AdipoRon (50 μM) attenuates the expression of TNF-α and TGF-β1, apparently in a dose-dependent manner in the L02 cells. AdipoRon exhibits significant and dosage-dependent growth suppression on macrophages[1]. AdipoRon treatment significantly improves cardiac functional recovery after reperfusion, and inhibits post-MI apoptosis[2]. AdipoRon exerts vasodilation by mechanisms distinct to adiponectin. AdipoRon induces vasorelaxation without a marked decrease in VSMC [Ca2+]i[3].
      • 体内研究:
      • AdipoRon (0.02, 0.1, and 0.5 mg/kg, i.g.) alleviates D-GalN induced hepatotoxicity in mice. AdipoRon dose-dependently prevents hepatic architecture distortion against D-GalN challenge. The hepatoprotective potential of AdipoRon is particularly evident in higher dosages (0.1 and 0.5 mg/kg)[1]. Enhanced cardiomyocyte apoptosis in APN-deficient mice is rescued by AdipoRon (50 mg/kg, p.o.) administration. Antiapoptotic effect of AdipoRon is attenuated but not lost in AMPK-DN mice[2].
      • 简介:
      • AdipoRon is a novel small-molecule AdipoR agonist; binds to both AdipoR1(Kd= 1.8 uM) and AdipoR2(Kd=3.1 uM). Kd: 1.8 μM (AdipoR1), 3.1 μM (AdipoR2)
      • 特异性:
      • Target: Adiponectin Receptor. Fields: AdipoRon is a novel small-molecule AdipoR agonist; binds to both AdipoR1(Kd= 1.8 uM) and AdipoR2(Kd=3.1 uM). Kd: 1.8 μM (AdipoR1), 3.1 μM (AdipoR2)
      • 来源:
      • Rabbit
      • 稀释:
      • Kd: 1.8 μM (AdipoR1), 3.1 μM (AdipoR2)
      • 浓度:
      • >98%
      • 储存:
      • 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
      • 分子量:
      • 428.52
      • 产品图片