AZD1208

    • 货号:MC0159
      • CasNo:
      • 1204144-28-4
      • 分子式:
      • C21H21N3O2S
      • 纯度:
      • >98%
      • 靶点:
      • Pim
      • IC50:
      • No data
      • 体外研究:
      • AZD1208 shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI50 values less than 100 nM[1]. AZD1208 (10 μM) inhibits the growth of Ramos cells, and at 1 μM, strongly inhibits PIM kinases in all cell at 1 μM. AZD1208 induces apoptosis, and PIM2 knockdown is mainly associated with an alteration of the cell cycle[2]. The combination of AZD1208 and AZD2014 rapidly activates AMPKα, a negative regulator of translation machinery through mTORC1/2 signaling in AML cells; profoundly inhibits AKT and 4EBP1 activation; and suppresses polysome formation[3]
      • 体内研究:
      • 简介:
      • AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.
      • 特异性:
      • Target: Pim. Fields: AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.
      • 来源:
      • Rabbit
      • 稀释:
      • WB 1:500-2000
      • 浓度:
      • >98%
      • 储存:
      • 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
      • 其他名称:
      • AZD-1208;, AZD1208;, AZD 1208.
      • 分子量:
      • 379.48
      • 产品图片