Torin1

    • 货号:MC0121
      • CasNo:
      • 1222998-36-8
      • 分子式:
      • C35H28F3N5O2
      • 纯度:
      • >98%
      • 靶点:
      • mTOR
      • IC50:
      • IC50: 2 nM (mTORC1), 10 nM (mTORC2)
      • 体外研究:
      • Torin1 (250 nM) completely inhibits proliferation and causes a G1/S cell cycle arrest, and decreases cell size to a greater degree than 50 nM rapamycin in wild-type MEFs[1]. Torin1 has more than 800-fold selectivity between mTOR and PI3Kis, and is very selective relative to other PIKK family kinases with the exception of DNA-PK[2].
      • 体内研究:
      • Torin1 (20 mg/kg, i.p.) is efficacious in a U87MG xenograft model, and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues[2].
      • 简介:
      • Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.
      • 特异性:
      • Target: mTOR. Fields: Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.
      • 稀释:
      • IC50: 2 nM (mTORC1), 10 nM (mTORC2)
      • 浓度:
      • >98%
      • 储存:
      • 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
      • 其他名称:
      • Torin-1,Torin 1
      • 分子量:
      • 607.62
      • 产品图片