CD94 rabbit pAb

  • Catalog No.：YT7838
  • Applications：WB;ELISA
  • Reactivity：Human;Rat;Mouse;
    • Target：
    • CD94
    • Fields：
    • >>Antigen processing and presentation;>>Natural killer cell mediated cytotoxicity;>>Graft-versus-host disease
    • Gene Name：
    • KLRD1 CD94
    • Protein Name：
    • CD94
    • Human Gene Id：
    • 3824
    • Human Swiss Prot No：
    • Q13241
    • Mouse Swiss Prot No：
    • O54707
    • Immunogen：
    • Synthesized peptide derived from human CD94 AA range: 124-173
    • Specificity：
    • This antibody detects endogenous levels of Human CD94
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:1000-2000 ELISA 1:5000-20000
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Natural killer cells antigen CD94 (KP43;Killer cell lectin-like receptor subfamily D member 1;NK cell receptor;CD antigen CD94)
    • Molecular Weight(Da)：
    • 20kD
    • Background：
    • Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
    • Function：
    • function:Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.,online information:CD94,similarity:Contains 1 C-type lectin domain.,subunit:Can form disulfide-bonded heterodimer with NKG2 family members.,tissue specificity:Natural killer cells.,
    • Subcellular Location：
    • Cell membrane ; Single-pass type II membrane protein .
    • Expression：
    • Expressed in NK cell subsets (at protein level) (PubMed:21825173, PubMed:9430220, PubMed:9485206). Expressed in memory/effector CD8-positive alpha-beta T cell subsets (at protein level) (PubMed:12387742, PubMed:20952657). Expressed in melanoma-specific cytotoxic T cell clones (at protein level) (PubMed:9485206). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level) (PubMed:20952657). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed in NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level) (PubMed:20952657).

    Attributes

    • Code：
    • YT7838
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-04-24
    Order

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