• Target：
• Txk

• Fields：
• >>Leukocyte transendothelial migration

• Gene Name：
• TXK

• Protein Name：
• Tyrosine-protein kinase TXK

• Human Gene Id：
• 7294

• Human Swiss Prot No：
• P42681

• Mouse Swiss Prot No：
• P42682

• Immunogen：
• Synthesized peptide derived from the Internal region of human Txk.

• Specificity：
• Txk Polyclonal Antibody detects endogenous levels of Txk protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TXK;PTK4;RLK;Tyrosine-protein kinase TXK;Protein-tyrosine kinase 4;Resting lymphocyte kinase

• Molecular Weight(Da)：
• 61kD

• Background：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,tissue specificity:Expressed in T-cells and some myeloid cell lines.,

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,tissue specificity:Expressed in T-cells and some myeloid cell lines.,

• Subcellular Location：
• Cytoplasm . Nucleus . Cell membrane ; Peripheral membrane protein . Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.

• Expression：
• Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential.

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